Decoding Cell Division in Mycobacteria: From Molecular Machinery to Antimicrobial Innovation
- conference
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medicine
The bacterial cell cycle relies on the construction of the cell wall by two distinct protein groups: elongasome and divisome. These mechanisms remain insufficiently understood, especially in Mycobacterium tuberculosis, one of the most lethal human pathogens. Exhibiting polar growth and a complex multilayered cell wall, this pathogen presents unique challenges. Our aim is to fill the knowledge gaps in these machineries using cell biology and interactomics assisted by mass spectrometry. Through biophysical, cellular analyses, and structural biology, we explore their functions and architectures. By assessing changes triggered by disrupting these machineries, we aim to discover new antibiotics targeting these systems. An advanced imaging system, assisted by AI, is being developed in a safe bacterial model to identify and analyze these new antimycobacterial compounds.
Good to know
The event delves into the unique challenges posed by the cell wall of Mycobacterium tuberculosis, a complex bacteriological model, and innovations in imaging and the development of new antibiotics.
Automatically translated from French.
Where does it take place?
Luxembourg Institute of Science and Technology (LIST)
37D Av. John F. Kennedy
1855 Kirchberg Luxembourg
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